EVALUATION OF THE AVAILABLE CHOLESTEROL CONCENTRATION IN THE INNER LEAFLET OF THE PLASMA MEMBRANE OF MAMMALIAN CELLS

Evaluation of the available cholesterol concentration in the inner leaflet of the plasma membrane of mammalian cells

Cholesterol is an essential component of the mammalian plasma membrane involved in diverse cellular processes.Our recent quantitative imaging analysis using Dynamic Brake Resistor ratiometric cholesterol sensors showed that the available cholesterol concentration in the inner leaflet of the plasma membrane (IPM) is low in unstimulated cells and inc

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Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development.

BackgroundCancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer Elixir development.The accumulated genetic changes can be detected when gene expression levels in advanced-stage are less variable but show high variability in early-stage.Normalizing advanced-stage expression samples wi

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